Table 3.
IC50 (UM) of ligands 1–3 and 9, DPPF oxide and metal complexes 4–8, 10–11 and cisplatin in human cell lines.a All compounds were dissolved in 1% of DMSO and diluted with water before addition to cell culture medium for a 74 h incubation period. Cisplatin was dissolved in H2O.
| A2780 | A2780cisR | MCF7 | HEK-293T | |
|---|---|---|---|---|
| 1 | 40.3 ±5.2 | 32.7 ±6.0 | - | 45 ±5.0 |
| 2 | 5.3±0.8 | 13.1±4.0 | 15.0±6.0 | 10.5±4.0 |
| 3 | 36.7±6.0 | 30.3 ±1.6 | - | >50 |
| 4 | 1.4 ±0.8 | 1.3 ±1.0 | 3.0±0.8 | 1.2±0.6 |
| 5 | 2.7±0.8 | 2.4±0.5 | 3.5±1.5 | 4.0±0.8 |
| 6 | 2.0±0.4 | 1.8±0.7 | 3.0±0.6 | 5.6±0.3 |
| 7 | 30.1±5.0 | 25.2±4.3 | 40.0±7.0 | 32.2±5.0 |
| 8 | 17.4±4 | 11.9±2.5 | 10.2±3.7 | 15.0±3.2 |
| 9 | >100 | >50 | >100 | >100 |
| 10 | 19.0±1.1 | 8.0±2.4 | 30.0±3.8 | 30.5±1.5 |
| 11 | 7.1±1.7 | 6.2±0.3 | 25.0±4.3 | 45.0±5.0 |
| DDPF-oxide | 113±72 | 85±38 | >50 | >50 |
| cisplatinb | 1.9±0.6 | 35±7.0 | 20.0±3.0 | 11.0±2.9 |
a
Data are expressed as mean ± SD (n =4).
b
Ref. 18.