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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Org Lett. 2013 Nov 1;15(22):10.1021/ol402904d. doi: 10.1021/ol402904d

Table 4 .

Reaction Scope with Respect to Amides

graphic file with name nihms537547t19.jpg
entry Ar product yield,
%
1 4-CNC6H4 graphic file with name nihms537547t20.jpg 55
2 4-CF3C6H4 graphic file with name nihms537547t21.jpg 74
3 4-NO2C6H4 graphic file with name nihms537547t22.jpg 59
4 3,4-(OMe)2C6H4 graphic file with name nihms537547t23.jpg 57
5 3-MeOC6H4 graphic file with name nihms537547t24.jpg 54
6 3-MeC6H4 graphic file with name nihms537547t25.jpg 60
7 4-C5H4N graphic file with name nihms537547t26.jpg 51
8b 4-C5H4N graphic file with name nihms537547t27.jpg 47
a

Scale: 0.5 mmol; time: 2–8 h; 1/1 amide/alcohol ratio, 90–110 °C, 11% catalyst = 22 mol % Cu. Please see Supporting Information for details.

b

Amide/alcohol ratio: 1/3, DMPU solvent.