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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: J Med Chem. 2013 Jun 20;56(13):10.1021/jm400405z. doi: 10.1021/jm400405z

Figure 5.

Figure 5

Yonetani-Theorell plot for inhibition of HIV-1 RT-RNase H activity in the presence of β-thujaplicinol and (a) Compound 9 or (b) Compound 29. The inhibitory activity (defined as V0/Vi) for each concentration of β-thujaplicinol (β-TP: 0, 0.125, 0.25, 0.5, and 1 μM) is plotted as a function of the concentrations of the thienopyrimidinone inhibitors (0, 0.625, 1.25, 2.5, and 5 μM). The assay was performed at fixed concentrations of substrate and enzyme (250 nM and 17 nM, respectively).