. Author manuscript; available in PMC: 2014 Jul 11.

Published in final edited form as: J Med Chem. 2013 Jun 20;56(13):10.1021/jm400405z. doi: 10.1021/jm400405z

Table 2.

Inhibition of HIV-1 RNase H enzymatic activity by thienopyrimidinones carrying C₂ heteroaromatic substitutions. IC₅₀ values represent the average of triplicate analysis.



Compound	Ar	IC₅₀ (μM)
16		8.3 ±0.2
17		4.2 ± 0.05
18		0.48 ± 0.06
19		16.9 ±1.7