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Model of striatal nNOS regulation (adapted from West, 2010). nNOS-containing interneurons receive input from corticostriatal and nigralstriatal projections. nNOS-containing interneurons express both NMDA and D1 receptors. Stimulation of NMDA receptors activates nNOS to produce NO. In addition to corticostriatal activation of NMDA receptors, nigrostriatal DA inputs activate D1 receptors, increasing nNOS activity.
