Table 2.
Genotype and allele frequencies of TP53 signaling pathway gene polymorphisms.
| Fertile n (%) | Endometriosis n (%) | P value* | IVF Failure n (%) | P value** | |
|---|---|---|---|---|---|
|
MDM2 rs2279744 |
|||||
| TT | 57 (42.5) | 41 (41.8) | 0.824 | 48 (41.7) | 0.918 |
| TG | 64 (47.8) | 45 (45.9) | 54 (47) | ||
| GG | 13 (9.7) | 12 (12.2) | 13 (11.3) | ||
| G | 0.67 | 0.65 | 0.765 | 0.65 | 0.765 |
| T | 0.33 | 0.35 | 0.35 | ||
|
MDM4 rs1563828 |
|||||
| CC | 34 (25.4) | 34 (34.7) | 0.268 | 40 (34.8) | 0.141 |
| CT | 71 (53) | 43 (42.9) | 59 (51.3) | ||
| TT | 29 (21.6) | 21 (21.4) | 16 (13.9) | ||
| C | 0.52 | 0.57 | 0.477 | 0.6 | 0.254 |
| T | 0.48 | 0.43 | 0.4 | ||
|
HAUSP rs1529916 |
|||||
| CC | 73 (54.5) | 53 (54.1) | 0.977 | 53 (46.1) | 0.224 |
| CT | 52 (38.8) | 39 (39.8) | 48 (41.7) | ||
| TT | 9 (6.7) | 6 (6.1) | 14 (12.2) | ||
| C | 0.74 | 0.74 | 1 | 0.67 | 0.277 |
| T | 0.26 | 0.26 | 0.33 | ||
|
LIF rs929271 |
|||||
| TT | 57 (42.5) | 47 (48) | 0.702 | 46 (40) | 0.784 |
| TG | 60 (44.8) | 39 (39.8) | 51 (44.3) | ||
| GG | 17 (12.7) | 12 (12.2) | 18 (15.7) | ||
| T | 0.65 | 0.68 | 0.653 | 0.62 | 0.659 |
| G | 0.35 | 0.32 | 0.38 | ||
|
ESR1 rs9340799 |
|||||
| AA | 71 (53) | 27 (27.6) | <0.001 | 45 (39.1) | 0.018 |
| AG | 54 (40.3) | 55 (56.1) | 51 (44.3) | ||
| GG | 9 (6.7) | 16 (16.3) | 19 (16.5) | ||
| A | 0.73 | 0.55 | 0.008 | 0.61 | 0.071 |
| G | 0.27 | 0.45 | 0.39 | ||
|
ESR1 rs2234693 |
|||||
| CC | 27 (20.1) | 18 (18.4) | 0.861 | 17 (14.8) | 0.105 |
| CT | 69 (51.5) | 54 (55.1) | 51 (44.3) | ||
| TT | 38 (28.4) | 26 (26.5) | 47 (40.9) | ||
| C | 0.46 | 0.46 | 1 | 0.37 | 0.196 |
| T | 0.54 | 0.54 | 0.63 |
*Chi-square analysis for the difference between Fertile and Endometriosis groups. **Chi-square analysis for the difference between Fertile and IVF Failure groups.