Table 4.
Demographic and metabolic characteristics based on FADS variants or FADS haplotype.
| SNP/haplotypes | FADS1 rs174537 | FADS2 rs174570 | 11 | 13 | 14 | 33 | 34 | ||
|---|---|---|---|---|---|---|---|---|---|
| Genotype/allele/haplotype genotypes | GG genotype (n = 167) | T allele (n = 150) | CC genotype (n = 236) | T allele (n = 83) | GC/GC (n = 163) | GC/TC (n = 61) | GC/TT (n = 56) | TC/TC (n = 11) | TC/TT (n = 18) |
|
| |||||||||
| Age (years) | 42.8 ± 11.6 | 42.1 ± 11.9 | 43.2 ± 11.8 | 40.4 ± 11.2 | 43.0 ± 11.5 | 43.0 ± 11.6 | 39.3 ± 11.8 | 46.6 ± 16.7 | 44.3 ± 9.30 |
| Gender (% female) ¥# | 37 | 52 | 44 | 48 | 37 | 54 | 50 | 73 | 33 |
| Race (% Caucasian/% African American/% other*)¥ψ# | 57/34/9 | 83/8/9 | 65/27/8 | 81/8/11 | 57/35/8 | 82/10/8 | 78/11/11 | 100/0/0 | 94/6/0 |
| Current smokers (%) | 48 | 47 | 47 | 47 | 48 | 51 | 43 | 27 | 61 |
| Currently on AAP (%) | 78 | 85 | 81 | 84 | 78 | 88 | 85 | 91 | 73 |
| BMI (kg/m2)ψ | 31.3 ± 7.63 | 31.7 ± 7.91 | 31.0 ± 7.62 | 33.0 ± 7.92 | 31.4 ± 7.71 | 30.5 ± 7.61 | 33.5 ± 8.68 | 27.7 ± 5.99 | 31.2 ± 6.34 |
| SBP (mmHg) | 123 ± 16.1 | 121 ± 16.9 | 122 ± 16.4 | 123 ± 16.9 | 123 ± 15.9 | 119 ± 16.9 | 122 ± 14.4 | 121 ± 21.5 | 127 ± 21.7 |
| DBP (mmHg) | 74.3 ± 11.0 | 73.2 ± 11.6 | 74.0 ± 10.7 | 73.1 ± 12.7 | 74.4 ± 10.9 | 73.0 ± 10.7 | 73.2 ± 11.5 | 71.9 ± 6.95 | 76 ± 15.5 |
| TC (mg/dL) | 184 ± 41.7 | 181 ± 44.6 | 183 ± 43.1 | 182 ± 42.6 | 183 ± 41.3 | 184 ± 48.9 | 180 ± 41.6 | 181 ± 40.5 | 171 ± 42.3 |
| TG (mg/dL) | 131 ± 94.0 | 138 ± 96.4 | 136 ± 101.5 | 126 ± 72.1 | 130 ± 93.8 | 162 ± 124 | 121 ± 65.9 | 104 ± 45.6 | 127 ± 85.2 |
| HDL (mg/dL) | 54.0 ± 17.0 | 54.6 ± 16.3 | 54.4 ± 17.4 | 54.4 ± 15.1 | 54.0 ± 17.2 | 52.7 ± 16.0 | 55.2 ± 16.5 | 65.2 ± 20.3 | 51.8 ± 13.0 |
| LDL (mg/dL) | 112 ± 37.6 | 109 ± 34.9 | 110 ± 37.8 | 112 ± 31.5 | 111 ± 37.5 | 110 ± 39.9 | 110 ± 31.0 | 103 ± 32.5 | 105 ± 32.9 |
| Glucose (mg/dL) | 98.3 ± 17.9 | 97.2 ± 15.1 | 98.1 ± 17.1 | 97.2 ± 15.4 | 98.1 ± 18.0 | 98.6 ± 15.5 | 96.4 ± 16.2 | 94.2 ± 12.9 | 95.8 ± 12.4 |
| Insulin (µIU/mL)# | 20.8 ± 12.3 | 22.4 ± 21.2 | 22.1 ± 18.4 | 19.7 ± 12.2 | 20.8 ± 12.3 | 27.3 ± 29.2 | 20.4 ± 13.9 | 15.7 ± 11.1 | 16.7 ± 6.51 |
| HOMA-IR# | 5.18 ± 3.74 | 5.49 ± 5.63 | 5.52 ± 5.13 | 4.72 ± 3.16 | 5.166 ± 3.74 | 6.90 ± 7.86 | 4.83 ± 3.54 | 3.89 ± 3.18 | 3.94 ± 1.61 |
*Other includes self-defined race categories of Asian, Hispanic, latino, and others.
¥Significant difference based on a P value cutoff of 0.05 for the FADS1 dominant genetic model.
ψSignificant difference based on a P value cutoff of 0.05 for the FADS2 dominant genetic model.
#Significant difference based on a P value cutoff of 0.05 for haplotype comparisons.