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. 2014 Jan 1;28(1):104–111. doi: 10.1089/end.2013.0380

Table 1.

Results of Fluorine-18 Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Studies in Patients with Histologically Confirmed Non-small Cell Lung Cancer and Adrenal Lesions

Study # NSCLC/patients (%) Mean size in cm (range) Histologic diagnosisa Sensitivity Specificity Miscellaneous
Erasmus 19976
24/27 (89%)
3.0 (1.0–9.0)
11
100 %
80%
PET/CT accurate in 23/23 true-positives; 2 false+patients had FDG uptake of 3.0 and 3.7
Gupta 20017
27/30 (90%)
NR
7
94.4%
91.6%
PET/CT accurate in 17/18 true-positives, 11/12 true-negatives; 1 false-negative+adrenal schwannoma
Sung 20088
39/42 (87%)
1.6 (0.5–10.4)
9
80%
89%
PET/CT accurate in 28/35 true-positives and 23/26 true-negatives
Brady 20099
NR/76b
2.2±1.4c
12
97%
86%
92 excluded masses; PET/CT using strict SUVmax and ratio criteria accurate in 22/37 true-positives and 58/58 true-negatives
Okada 200910
23/30 (77%)
2.0±0.85c
0
89%
94%
PET/CT using strict SUVmax and ratio criteria accurate in accurate in 18/19 true-positives and 16/16 true-negatives
Lu 201011
NR/87
1.8 (0.4–5.8)
3
97%
94%
PET/CT accurate in 74/77 true-positives and 31/33 true-negatives
Cho 201112
43/51 (84%)
2.8 (1.0–7.2)
2
97%
81%
PET/CT accurate in 43/45 true-positives and 13/16 true-negatives using strict SUVmax and ratio criteria
Total NC/343 2.2 (0.4–10.4) 44 94% 85% Limitations: Many studies exclude indeterminate masses or questionable lesions with insufficient follow-up
a

Nonhistologic adrenal mass determination made by CT change in nodule at ≥6 follow-up (malignancy=nodule growth; benign=stable or reduced nodule size).

b

Some patients had “suspected” lung cancer.

c

Mean lesion size±standard deviation.

NSCLC=non-small cell lung cancer; PET/CT=positron-emission tomography/computed tomography; FDG=fluorine-18 fluorodeoxyglucose; NR=not reported; SUV=standard uptake value; NC=not calculable because of missing variables.