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. 2014 Jan 1;20(1):31–41. doi: 10.1089/ars.2012.5119

FIG. 4.

FIG. 4.

NaHS treatment attenuated morphine-induced elevation of cAMP level and CREB phosphorylation in the striatum of mice. (A) Effect of NaHS on cAMP production in the striatum of morphine-treated mice. Mean±S.E.M, n=9. (B, C) Effect of NaHS pretreatment on the up-regulation of CREB phosphorylation induced by naloxone-precipitated withdrawal in mice striatum. Mean±S.E.M, n=4. *p<0.05, **p<0.01, versus Con; #p<0.05, versus Mor. Con, control; Mor, morphine; S, NaHS; CREB, cAMP response element-binding protein.