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. 2014 Jan 1;20(1):31–41. doi: 10.1089/ars.2012.5119

FIG. 8.

FIG. 8.

Role of ERK1/2 in CREB phosphorylation in DAMGO-treated SH-SY5Y cells. (A, B) Western blots showing the effects of NaHS and inhibition of ERK1/2 on naloxone-induced CREB phosphorylation in SH-SY5Y cells. Mean±S.E.M, n=4. ***p<0.001, versus Con; ###p<0.001, versus D+Nal. (C, D) Western blots showing the effect of CBS over-expression on the up-regulated p-ERK1/2 induced by naloxone-precipitated withdrawal in SH-SY5Y cells. Mean±S.E.M, n=4. **p<0.01, versus Con; ##p<0.01, versus D+Nal. Con, control; S, NaHS; D, DAMGO; Nal, naloxone; PD, PD98059; t-ERK, total ERK; ERK1/2, extracellular regulated protein kinase 1/2.