Table 3.
Factors Associated with Poor Short Physical Performance Battery Score
| Characteristic | SPPB≤9 n=13 | SPPB>9 n=52 | p-value |
|---|---|---|---|
| Demographic variables | |||
| Age (years) |
55 (48–56) |
48 (44–54) |
0.06 |
| Race/ethnicity | |||
| Black |
9 (69) |
35 (67) |
1.0 |
| White |
1 (8) |
5 (10) |
|
| Hispanic |
2 (15) |
9 (17) |
|
| Other |
1 (8) |
3 (6) |
|
| Current cigarette smoker |
8 (62) |
14 (27) |
0.03 |
| Current illicit drug use (n=64) |
0 |
6 (12) |
0.33 |
| General medical variables | |||
| Body mass index |
30.5 (25.6–34.5) |
27.9 (23.8–32.4) |
0.38 |
| Hypertension |
9 (69) |
23 (44) |
0.13 |
| Hepatitis C infection |
6 (46) |
12 (23) |
0.16 |
| Hyperlipidemia |
4 (31) |
14 (27) |
0.74 |
| Diabetes |
6 (46) |
10 (19) |
0.07 |
| Number of comorbid medical conditionsa | |||
| 0 |
1 (8) |
15 (29) |
0.01 |
| 1–2 |
7 (54) |
33 (63) |
|
| 3 or more |
5 (38) |
4 (8) |
|
| HIV variables | |||
| Nadir CD4 count (cells/mm3) (n=61) |
202 (70–223) |
200.5 (125–269.5) |
0.51 |
| Current CD4 count (cells/mm3) |
595 (471–826) |
678.5 (427–831.5) |
0.95 |
| Current HIV viral load ≤75 copies/mL |
10 (77) |
48 (92) |
0.14 |
| Component scores of Short Physical Performance Battery | |||
| Balance |
4 (3–4) |
4 (4–4) |
0.054 |
| Walking speed |
3 (3–3) |
4 (4–4) |
<0.0001 |
| Chair stand time |
2 (1–3) |
4 (3.5–4) |
<0.0001 |
| Inflammatory Variables | |||
| sTNFR1 (ng/mL) (n=62) |
2.0 (1.7–2.5) |
1.6 (1.3–1.8) |
0.09 |
| sCD14 (ug/mL) (n=62) |
2.0 (1.5–2.2) |
1.7 (1.6–2.0) |
0.84 |
| TGFB1 (ng/mL) (n=59) |
25.4 (19.1–47.8) |
32.2 (17.5–40.7) |
0.98 |
| IL-6 (pg/mL) (n=62) |
1 (0–3) |
0 (0–1) |
0.048 |
| HA (ng/mL) (n=61) |
1.5 (0–12.6) |
0.2 (0–2.6) |
0.17 |
| LPS (endotoxin unit) (n=61) | 0.8 (0.3–1.0) | 0.8 (0.4–1.2) | 0.54 |
Results presented as number (percent) or median (interquartile range).
a
Includes diagnosis of hypertension, hepatitis C, hyperlipidemia, diabetes, and coronary artery disease.
CD4, CD4 T-cell.