Table 3.
Impact of genetic knowledge, attitudes toward carrier status, and previous decision-making on Down syndrome investigations on test uptake.
| Variables | Accept test (N = 63) | Decline test (N = 137) | p-Value (univariate) | p-Valueb (multivariate) |
|---|---|---|---|---|
| Knowledge of geneticsa | ||||
| Median (IQR) | 5 (3–8.5) | 3 (1–8) | 0.03 | 0.19 |
| Attitudes to carrier status | ||||
| Emotional disadvantage | ||||
| No | 37 (69%) | 17 (31%) | <0.0001 | <0.0001 |
| Uncertain | 15 (22%) | 52 (78%) | ||
| Yes | 11 (14%) | 66 (86%) | ||
| Missing data | 0 | 2 | ||
| Insurance disadvantage | ||||
| No | 40 (80%) | 10 (20%) | <0.0001 | <0.0001 |
| Uncertain | 12 (15%) | 67 (85%) | ||
| Yes | 11 (16%) | 59 (84%) | ||
| Missing data | 1 | |||
| Employment disadvantage | ||||
| No | 42 (52%) | 38 (48%) | <0.0001 | <0.0001 |
| Uncertain | 11 (19%) | 48 (81%) | ||
| Yes | 10 (17%) | 50 (83%) | ||
| Missing data | 0 | 1 | ||
| Decision on down syndrome testing | ||||
| Underwent a test | 60 (55%) | 48 (45%) | <0.0001 | <0.0001 |
| Declined testing | 3 (3%) | 89 (97%) |
aRange 0–15: 0 = low knowledge, no correct answers in test to 15 = high knowledge, all answers correct in test.
bMultivariate analysis ANOVA included religion, education, income, family history of cancer, knowledge of genetics, emotional disadvantage, insurance disadvantage and employment disadvantage, and previous behavior in relation to Down syndrome testing in the preceding pregnancy.