Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Dec 26;8:47. doi: 10.1186/1750-1326-8-47

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2013 Unterwald et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Baseline striatal TrkB level and locomotor activity in D9ΔTrkB mice. (a) Baseline levels of striatal TrkB.FL and TrkB.T1 are equal in fB/fB male and female mice. Densitometric values were normalized to actin. Blot is representative of N = 6, p > 0.05 (t-test). (b) Relative to fB/fB, D9ΔTrkB male and female mice demonstrate approximately a 50% decrease in striatal TrkB.FL (N = 3–4,*** P < 0.005, t-test). There is a trend towards a small decrease in TrkB.T1 (N = 3, P = 0.06, t-test). Densitometric values were normalized to actin, and fB/fB levels were arbitrarily set to equal 1. (c) Down-regulation of striatal MSN TrkB.FL does not alter baseline total activity, but there is a genotype-independent increase in activity in female mice relative to males (N = 8-12/group, ** P < 0.01 two-way ANOVA for sex factor).