Table 3.
Determinants of the rate of eGFR slope in study patients
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| Unstandardized coefficient β (95% CI) |
p | Unstandardized coefficient β (95% CI) |
p | ||
| Age (years) | 0.03 (-0.43, -0.10) | 0.422 | - | ||
| Male (%) | 2.44 (0.34, 4.53) | 0.023 | 1.30 (-0.73, 3.34) | 0.208 | |
| BMI (kg/m2) | 0.21 (0.00, 0.42) | 0.052 | 0.07 (-0.14, 0.29) | 0.500 | |
| Diabetes | 0.20 (-2.03, 2.26) | 0.913 | - | ||
| Coronary artery disease (%) | 1.75 (-1.01, 4.51) | 0.212 | - | ||
| Heart failure (%) | 0.21 (-3.78, 4.18) | 0.919 | - | ||
| Cerebrovascular disease (%) | 0.84 (-1.97, 3.65) | 0.556 | - | ||
| Liver cirrhosis (%) | 1.34 (-3.97, 6.65) | 0.619 | - | ||
| COPD (%) | 1.40 (-4.85, 7.65) | 0.659 | - | ||
| Autoimmune disease (%) | 2.37 (-5.65, 10.39) | 0.560 | - | ||
| MAP (mmHg) | -0.04 (-0.15, 0.08) | 0.518 | -0.06 (-0.18, 0.05) | 0.268 | |
| Unresolved subclinical hypothyroidism | -5.63 (-8.79, -2.46) | 0.001 | -5.77 (-9.13, -2.42) | 0.001 | |
| eGFR (ml/min/1.73 m2) | -0.10 (-0.16, -0.03) | 0.003 | -0.12 (-0.19, -0.06) | <0.001 | |
| Laboratory data | |||||
| Hemoglobin (g/dL) | 0.35 (-0.16, 0.85) | 0.174 | - | ||
| Calcium (mg/dL) | 0.92 (-0.55, 2.38) | 0.220 | - | ||
| Phosphorus (mg/dL) | 0.23 (-1.09, 1.55) | 0.730 | - | ||
| Total cholesterol (mg/dL) | -0.02 (-0.04, 0.00) | 0.053 | -0.01 (-0.02, 0.01) | 0.631 | |
| Triglyceride (mg/dL) | 0.00 (-0.01, 0.01) | 0.910 | - | ||
| LDL (mg/dL) | 0.01 (-0.03, 0.04) | 0.808 | - | ||
| Albumin (g/dL) | 2.28 (0.86, 3.69) | 0.002 | 0.99 (-0.61, 2.59) | 0.223 | |
| Proteinuria (g/day) | -2.81 (-4.36, -1.27) | <0.001 | -2.36 (-4.25, -0.46) | 0.015 | |
| Neutrophil to lymphocyte ratio | 0.44 (-3.28, 4.17) | 0.814 | - | ||
| Medications | |||||
| Number of anti-hypertensive drugs | -0.22 (-1.03, 0.59) | 0.595 | - | ||
| ACEi or ARB use (%) | -0.84 (-3.05, 1.36) | 0.452 | - | ||
Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; MAP, mean arterial pressure; eGFR, estimated glomerular filtration rate; LDL, low-density lipoprotein cholesterol; ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker.