Table 1.
Clinicopathological parameters and HPV L1 protein expression of HPV 16-positive abnormal cervical cytology (N =475).
| Total (N = 475) |
ASCUS† (n = 87) |
LSIL‡ (n = 253) |
HSIL§ (n = 94) |
Cancer (n = 41) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| number | (%) | number | (%) | number | (%) | number | (%) | number | (%) | p ¶ | |||
| HPV* L1 capsid immunocytochemistry | |||||||||||||
| Negative | 287 | (60.4) | 68 | (78.2) | 102 | (40.3) | 76 | (80.9) | 41 | (100.0) | <0.0001 | ||
| Positive | 188 | (39.6) | 19 | (21.8) | 151 | (59.7) | 18 | (19.1) | 0 | (0) | |||
| HPV 16 infection | |||||||||||||
| Single | 360 | (75.8) | 60 | (69.0%) | 204 | (80.6%) | 58 | (61.7%) | 38 | (92.7%) | <0.0001 | ||
| Multiple | 115 | (24.2) | 27 | (31.0%) | 49 | (19.4%) | 36 | (38.3%) | 3 | (7.3%) | |||
| Age (years) | |||||||||||||
| Mean age | 38.7 | 35.6 | 36.6 | 39.5 | 56.6 | <0.0001 | |||||||
| 20 - 29 | 129 | (26.6) | 23 | (26.4) | 83 | (32.8) | 23 | (24.5) | 0 | (0) | <0.0001 | ||
| 30 - 39 | 163 | (33.6) | 40 | (46.0) | 83 | (32.8) | 34 | (36.2) | 6 | (14.6) | |||
| 40 - 49 | 123 | (25.4) | 23 | (26.4) | 68 | (26.9) | 20 | (21.3) | 12 | (29.3) | |||
| ≥50 | 60 | (12.4) | 1 | (1.2) | 19 | (7.5) | 17 | (18.0) | 23 | (56.1) | |||
* HPV: human papillomavirus
†ASCUS: atypical squamous cells of undetermined significance
‡LSIL: low-grade squamous intraepithelial lesion
§HSIL: high-grade squamous intraepithelial lesion
¶ Evaluated by Fisher's Exact Test and t-test