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. 2014 Jan 6;4:509. doi: 10.3389/fimmu.2013.00509

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Copyright © 2014 Gardam and Brink.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenotypic outcomes of B cells in response to BAFF/BAFFR-mediated NF-κB2 activation. Activation of non-canonical NF-κB signaling in response to BAFF contributes to key events throughout the lifespan of a B cell. These include facilitating the survival of immature (Imm) B cells in the periphery and activating transcriptional programs which allow them to mature into follicular and marginal zone (MZ) B cells; contributing to some T-independent immune response; extending the duration of germinal center (GC) reactions; and maintaining long lived plasma cells (PCs) in the bone marrow. Refer to Section “Tissue Responses and Effector Functions: The Outcomes of NF-κB2 Signaling in Response to BAFF” of text for further details.