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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Cell Signal. 2013 Aug 29;25(12):10.1016/j.cellsig.2013.08.016. doi: 10.1016/j.cellsig.2013.08.016

Fig 2. TG2-induced activation of β-catenin is mediated by LRP6.

Fig 2

(A) Addition of exogenous purified gpTG2 activates β-catenin as shown by TOP-FLASH expression, which is augmented by overexpression of LRP6 in Cos-7 cells. (B) Dose-dependent induction of gpTG2-mediated β-catenin activation by LRP6. (C) LRP6 augmentation of gpTG2-induced β-catenin activation is inhibited by a monoclonal anti-LRP5/6 antibody 1A12, which blocks LRP6 receptor binding. (D) gpTG2-mediated activation of β-catenin signaling by LRP5+/− and LRP5−/− fibroblasts. Treatment with LRP6 shRNA shows that both LRP5 and LRP6 are required for this activation.