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(A) TG2 activity assay performed using stable levels of TG2 and Ez-link pentylamine with increasing doses of LRP6 shows that LRP6 inhibits TG2 cross-linking activity. (B) Western blot analysis of LRP6ΔC alone (left panel) or an LRP6ΔC/TG2 mixture (right panel) reveals formation of LRP6 complexes in the presence of gpTG2. (C) Induction of β-catenin activity by TG2 can be blocked by treatment with a TG2-specific inhibitor, KCC009.
