Table 2.
Effects of ZnPcS 4 -AN-based PDT and/or Dox treatments on erythrogram parameters of healthy and Ehrlich solid tumor-bearing mice
| Group | Treatment | RBC (x 10 6 /μL) | HGB (g/dL) | HCT (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | RDW (%) |
|---|---|---|---|---|---|---|---|---|
|
1 |
NC |
8.8 ± 0.1 |
12.8 ± 0.1 |
31.5 ± 0.3 |
35.8 ± 0.1 |
14.5 ± 0.1 |
40.5 ± 0.2 |
13.01 ± 0.09 |
|
2 |
CT |
8.6 ± 0.2 |
12.0 ± 0.2 |
30.7 ± 0.5 |
35.7 ± 0.3 |
13.9 ± 0.1**
a
|
38.9 ± 0.2**
a
|
13.6 ± 0.3 |
|
3 |
ZnPc |
6.6 ± 0.7**
a.
*
b
|
9.2 ± 0.9**
a.
*
b
|
23.3 ± 2.5**
a.
*
b
|
35.6 ± 0.4 |
14.2 ± 0.3 |
39.9 ± 0.5 |
14.1 ± 0.7 |
|
4 |
LS |
8.5 ± 0.1*
a.c
|
11.9 ± 0.2**
c
|
30.5 ± 0.5*
a.
**
c
|
36.0 ± 0.1 |
14.08 ± 0.08**
a
|
39.1 ± 0.2**
a
|
13.1 ± 0.2 |
|
5 |
PDT |
8.1 ± 0.2**
a.
*
b.d
|
11.4 ± 0.3**
c
|
29.0 ± 0.6**
a.
*
b
|
35.7 ± 0.2 |
14.0 ± 0.1 |
39.2 ± 0.2 |
14.0 ± 0.3 |
|
6 |
Dox |
7.8 ± 0.3 |
11.1 ± 0.3 |
30 ± 1 |
38 ± 2 |
14.1 ± 0.3 |
38 ± 1**
a
|
13.5 ± 0.4 |
|
7 |
ZnPc/Dox |
8.0 ± 0.4*
a
|
10.9 ± 0.5 |
28 ± 1**
a
|
35.25 ± 0.05 |
13.60 ± 0.00*
a.d
|
38.50 ± 0.00*
a.c.d
|
13.8 ± 0.4 |
|
8 |
Dox/LS |
7.6 ± 0.4**
a.
*
b.d
|
10.9 ± 0.5*
a
|
27 ± 1*
a.d.
**
b
|
35.8 ± 0.7 |
14.3 ± 0.1*
b
|
39.9 ± 0.5 |
13.5 ± 0.6 |
|
9 |
Dox/PDT |
8.3 ± 0.2
.
*
c.h
|
11.8 ± 0.2**
c
|
30.1 ± 0.6*
a.
**
c
|
36.2 ± 0.3 |
14.18 ± 0.12*
g
|
39.2 ± 0.1**
a.
*
g
|
14.2 ± 0.3 |
| P-values | 0.000 | 0.000 | 0.000 | 0.195 | 0.018 | 0.000 | 0.033 |
Data were expressed as mean ± SEM (standard error of mean). RBC = Red Blood Cells; HGB = Hemoglobin; HCT = Hematocrit; MCV = Mean Corpuscular Volume; MCH = Mean Corpuscular Hemoglobin; MCHC = Mean Corpuscular Hemoglobin Concentration; RDW = Red cell Distribution Width (represents an indication of the amount of variation - anisocytosis - in cell size); g/dL = grams per deciliter; fL = fentoliters; pg = picograms. P-values of HGB, MCV and RDW were generated by ANOVA, while other p-values were generated by Kruskal-Wallis test. Lower-case letters indicate significant diferences in 2-by-2 comparisons detected by Bonferroni (HGB, MCV and RDW) or Mann–Whitney (other variables) tests, with a = significant compared to group 1; b = significant compared to group 2; c = significant compared to group 3; d = significant compared to group 4; e = significant compared to group 5; f = significant compared to group 6; g = significant compared to group 7; h = significant compared to group 8. Asterisks indicate significant differences (*p < 0.05) or highly significant (**p < 0.01). For details of experimental groups see Table 5.