Table 3.
Effects of ZnPcS 4 -AN-based PDT and/or Dox treatments on plateletgram parameters of healthy and Ehrlich solid tumor-bearing mice
| G | Treatment | PLT (× 10 3 /μL) | MPV (fl) | P-LCR (%) | PDW (fl) |
|---|---|---|---|---|---|
|
1 |
NC |
1172 ± 50 |
6.31 ± 0.06 |
6.4 ± 0.3 |
6.77 ± 0.04 |
|
2 |
CT |
1496 ± 50**
a
|
6.5 ± 0.1 |
8.1 ± 0.9 |
6.80 ± 0.07 |
|
3 |
ZnPc |
1503 ± 300*
a
|
7.0 ± 0.1**
a
|
9.4 ± 0.5**
a
|
7.3 ± 0.2*
a
|
|
4 |
LS |
1366 ± 70*
a
|
6.54 ± 0.07 |
7.8 ± 0.5*
a
|
6.86 ± 0.07 |
|
5 |
PDT |
1528 ± 100**
a
|
6.7 ± 0.1 |
8.4 ± 0.6*
a
|
6.9 ± 0.1 |
|
6 |
Dox |
1312 ± 200 |
6.6 ± 0.3 |
8 ± 1 |
6.9 ± 0.3 |
|
7 |
ZnPc/Dox
(1)
|
1219 |
7.10 |
12.70 |
6.90 |
|
8 |
Dox/LS |
1808 ± 90**
a.
*
b.d
|
6.3 ± 0.2*
c
|
7 ± 2 |
6.53 ± 0.03**
a.
*
b.c.d
|
|
9 |
Dox/PDT |
1390 ± 80*
h
|
6.3 ± 0.1**
c
|
6 ± 1**
c
|
6.6 ± 0.1*
a.c
|
| P-values | 0.005 | 0.000 | 0.026 | 0.035 |
Data were expressed as mean ± SEM (standard error of mean). G = Group; PLT = Platelet Count; MPV = Mean Platelet Volume; P-LCR = Platelet Large Cell Ratio; PDW = Platelet Distribution Width; fl = fentoliters. P-values of MPV were generated by ANOVA, while other p-values were generated by Kruskal-Wallis test. Lower-case letters indicate significant diferences in 2-by-2 comparations detected by Bonferroni (MPV) or Mann–Whitney test (other variables), with a = significant compared to group 1; b = significant compared to group 2; c = significant compared to group 3; d = significant compared to group 4; h= significant compared to group 8. Asterisks indicate significant differences (*p < 0.05) or highly significant (**p < 0.01).
(1)Corresponds to the count of only one animal (the other samples coagulated). It was not used in statistical analyses of plateletgram. For details of experimental groups see Table 5.