Table 2:
Histopathologic criteria by main dermatoscopic pattern
| Reticular (n=28) | Dots/Structureless (n=13) | Clods (n=9) | |
|---|---|---|---|
| Scatter | |||
| No scatter, almost all melanocytes at the dermo-epidermal junction | 9 (32.1%) | 6 (46.2%) | 3 (33.3%) |
| 75–100% of melanocytes at the dermo-epidermal junction, <25% in higher layers of the epidermis | 13 (46.4%) | 7 (53.8%) | 6 (66.7%) |
| 50–75% of melanocytes at the dermo-epidermal junction, <50% in higher layers of the epidermis | 6 (21.4%) | 0 | 0 |
| More than 50% of melanocytes in higher levels of the epidermis | 0 | 0 | 0 |
| Nesting | |||
| Almost all melanocytes arranged as single cells | 8 (28.6%) | 5 (38.5%) | 0 |
| < 25% of melanocytes arranged in nests | 5 (17.9%) | 2 (15.4%) | 1 (11.1%) |
| 25–50% of melanocytes arranged in nests | 10 (35.7%) | 3 (23.1%) | 1 (11.1%) |
| >50% of melanocytes arranged in nests | 5 (17.9%) | 3 (23.1%) | 7 (77.8%) |
| Nest size | |||
| Intraepidermal melanocytes present almost exclusively as single cells | 11 (39.3%) | 7 (53.8%) | 1 (11.1%) |
| Intraepidermal nests predominantly arranged as small nests with no more than 25% large nests | 11 (39.3%) | 1 (7.7%) | 1 (11.1%) |
| 25–50% of the intraepidermal nests are large nests | 3 (10.7%) | 3 (23.1%) | 1 (11.1%) |
| >50% of the intraepidermal nests are large nests | 3 (10.7%) | 2 (15.4%) | 6 (66.7%) |
| Cell size | |||
| Smaller than that of basal keratinocytes | 9 (32.1%) | 8 (61.5%) | 1 (11.1%) |
| Larger than that of basal keratinocytes, but not larger than twofold | 18 (64.3%) | 5 (38.5%) | 7 (77.8%) |
| Larger than the twofold diameter of basal keratinocytes | 1 (3.6%) | 0 | 1 (11.1%) |