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(a) T1 weighted MR images of 3 nm-sized SPIONs. (b) Plot of 1/T1 over Fe concentration of SPIONs with diameters of 2.2 nm, 3 nm and 12 nm. The slope indicates the specific relaxivity (r1). (c, d) T1 weighted MR images of MCF-7 cell pellets after 24 h incubation with SPIONs with diameters of (c) 3 nm and (d) 12 nm. Reproduced with permission from Ref. 23. Copyright (2011) American Chemical Society.
