Table 4.
Multivariable analyses relating left ventricular hypertrophy patterns to incident heart failure.
Adjusted Hazards Ratio* for HF (95% CI) | ||||
---|---|---|---|---|
Normal LV | Concentric Remodeling | Concentric Hypertrophy | Eccentric Hypertrophy | p-value† |
A. All participants (n = 4768) | ||||
Referent | 1.09 (0.85-1.40) | 1.40 (1.04-1.87) | 1.89 (1.41-2.54) | 0.0002 |
B. Participants with normal FS (FS >0.29; n = 4700) | ||||
Referent | 1.21 (0.94-1.57) | 1.52 (1.13-2.05) | 1.78 (1.31-2.41) | 0.0009 |
C. Participants without clinical valve disease (n = 4678) | ||||
Referent | 1.16 (0.90-1.50) | 1.38 (1.02-1.87) | 1.70 (1.25-2.32) | 0.005 |
Hazard ratios indicate HF risk associated with individual hypertrophy patterns compared to the group with normal LV (referent), and adjusted for the following covariates: age, sex, body mass index, systolic blood pressure, valve disease, hypertension treatment, diabetes, total cholesterol/high density lipoprotein cholesterol ratio, smoking status, fractional shortening and interim MI.
P-value indicates statistical significance (p<0.05) for the global test for differences among the 4 LV patterns with respect to HF risk.