Table 1.

Genetic loci associated with coronary artery disease and/or myocardial infarction

Band	rs-number	Gene(s)	Risk allele	Risk allele frequency	OR (95% CI)	p-Value	Reference (examples)
1p13.3	rs599839	SORT1	A	0.77	1.29 (1.18-1.40)7	4.05 × 10−9	7, 17, 22
1p32.2	rs17114036	PPAP2B	A	0.91	1.17 (1.13-1.22)17	3.81 × 10−19	17
1p32.3	rs11206510	PCSK9	T	0.81	1.15 (1.10-1.21)22	9.6 × 10−9	22
1q21.3	rs4845625	IL6R	T	0.47	1.04 (1.02-1.07)20	3.55 × 10−8	20
1q41	rs17465637	MIA3	C	0.72	1.14 (1.10-1.19)22	1.4 × 10−9	7, 17, 22
2p11.2	rs1561198	VAMP5-VAMP8-GGCX	A	0.45	1.05 (1.03-1.07)20	4.48 × 10−9	20
2p21	rs6544713	ABCG5-ABCG8	T	0.30	1.06 (1.04-1.09)20	8.72 × 10−10	20, 25, 55
2p24.1	rs2123536	TTC32-WDR35	T	0.39	1.12 (1.08-1.16)19	6.83 × 10−11	19
2p24.1	rs515135	APOB	G	0.83	1.08 (1.05-1.11)20	4.80 × 10−10	20
2q22.3	rs2252641	ZEB2-AC074093.1	G	0.46	1.04(1.02-1.06)20	3.66 × 10−8	20
2q33.2	rs6725887	WDR12	C	0.14	1.17 (1.11-1.23)22	1.3 × 10−8	17, 22
3q22.3	rs2306374	MRAS	C	0.18	1.12 (1.07-1.16)17	3.34 × 10−8	17, 21
4q31.22	rs1878406	EDNRA	T	0.15	1.06 (1.02-1.11)20	2.54 × 10−8	20
4q32.1	rs7692387	GUCY1A3	G	0.81	1.06 (1.03-1.09)20	4.57 × 10−9	19, 20
5q31.1	rs273909	SLC22A4-SLC22A5	C	0.14	1.09 (1.05-1.12)20	1.43 × 10−8	20
6p21.2	rs10947789	KCNK5	T	0.76	1.06 (1.03-1.08)20	1.63 × 10−8	20
6p21.31	rs17609940	ANKS1A	G	0.75	1.07 (1.05-1.10)17	1.36 × 10−8	17
6p21.32	rs9268402	C6orf10-BTNL2	G	0.59	1.16 (1.12-1.20)19	2.77 × 10−15	19
6p21.33	rs3869109	HLA-C, HLA-B, HCG27	G	0.55	1 1456*	1.12 × 10−9	56
6p24.1	rs12526453	PHACTR1	C	0.65	1.12 (1.08-1.17) 22	1.3 × 10−9	17, 22
6p24.1	rs6903956	C6orf105	A	0.07	1.65 (1.44-1.90)57	2.55 × 10−13	57
6q23.2	rs12190287	TCF21	C	0.62	1.08 (1.06-1.10)17	1.07 × 10−12	17
6q25.3	rs3798220	LPA	C	0.02	1.51 (1.33-1.70)17	3.00 × 10−11	17, 23
6q26	rs4252120	PLG	T	0.73	1.06 (1.03-1.09)20	5.00 × 10−9	20
7p21.1	rs2023938	HDAC9	G	0.10	1.07 (1.04-1.11)20	4.94 × 10−8	20
7q22.3	rs10953541	BCAP29	C	0.8	1.08 (1.05-1.11)16	3.12 × 10−8	16
7q32.2	rs11556924	ZC3HC1	C	0.62	1.09 (1.07-1.12)17	9.18 × 10−18	17
8p21.3	rs264	LPL	G	0.86	1.05 (1.02-1.08)20	5.06 × 10−9	20
8q24.13	rs2954029	TRIB1	A	0.55	1.04 (1.02-1.06)20	4.53 × 10−8	20, 25
9p21.3	rs1333049	CDKN2A, CDKN2B	C	0.47	1.37 (1.26-1.48)7	1.80 × 10−14	7-9
9q34.2	rs579459	ABO	C	0.21	1.10 (1.07-1.13)17	4.08 × 10−14	17, 55, 58
10p11.23	rs2505083	KIAA1462	C	0.38	1.07 (1.04-1.09)16	3.87 × 10−8	16, 18
10q11.21	rs1746048	CXCL12	C	0.84	1.17 (1.11-1.24)22	7.4 × 10−9	7, 17, 22
10q23.31	rs1412444	LIPA	T	0.42	1.09 (1.07-1.12)16	2.76 × 10−13	16, 25, 59
10q24.32	rs12413409	CYP17A1, CNNM2,NT5C2	G	0.89	1.12 (1.08-1.16)17	1.03 × 10−9	17
11q22.3	rs974819	PDGFD	T	0.32	1.07 (1.04-1.09)16	2.41 × 10−9	16
11q23.3	rs964184	ZNF259, APOA5-A4-C3-A1	G	0.13	1.13 (1.10-1.16)17	1.02 × 10−17	17
12q21.33	rs7136259	ATP2B1	T	0.39	1.11 (1.08-1.15)19	5.68 × 10−10	19
12q24.12	rs3184504	SH2B3	T	0.38	1.13 (1.08-1.18)60	8.6 × 10−8	20, 60
13q12.3	rs9319428	FLT1	A	0.32	1.05 (1.03-1.08)20	1.01 × 10−8	20
13q34	rs4773144	COL4A1,COL4A2	G	0.44	1.07 (1.05-1.09)17	3.84 × 10−9	17
14q32.2	rs2895811	HHIPL1	C	0.43	1.07 (1.05-1.10)17	1.14 × 10−10	17
15q25.1	rs3825807	ADAMTS7	A	0.57	1.08 (1.06-1.10)17	1.07 × 10−12	16, 17, 58
15q26.1	rs17514846	FURIN-FES	A	0.44	1.05 (1.03-1.08)20	4.49 × 10−10	20
17p11.2	rs12936587	RASD1,SMCR3,PEMT	G	0.56	1.07 (1.05-1.09)17	4.45 × 10−10	17
17p13.3	rs216172	SMG6, SRR	C	0.37	1.07 (1.05-1.09)17	1.15 × 10−9	17
17q21.32	rs46522	UBE2Z, GIP,ATP5G1, SNF8	T	0.53	1.06 (1.04-1.08)17	1.81 × 10−8	17
19p13.2	rs1122608	LDLR	G	0.75	1.15 (1.10-1.20)22	1.9 × 10−9	17, 22
19q13.32	rs2075650	APOE/TOMM40	G	0.14	1.14 (1.09-1.19)25	3.2 × 10−8	20, 25
21q22.11	rs9982601	SLC5A3-MRPS6-KCNE2	T	0.13	1.20 (1.14-1.27)22	6.4 × 10−11	17, 22

^*The 95% confidence interval of the odds ratio was not numerically provided.

In each row, data on rsnumber, gene(s) at the locus, risk allele, risk allele frequency and p-value, were obtained from the same reference as the odds ratio