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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: J Am Coll Cardiol. 2012 Mar 27;59(13):10.1016/j.jacc.2011.10.900. doi: 10.1016/j.jacc.2011.10.900

Figure 2. Mechanisms of pulmonary hypertension in SCD patients.

Figure 2

A pulmonary vessel with severe intimal and smooth muscle proliferation is shown from a 35 year old patient with SCD who died suddenly with known PAH. Mechanisms that contribute to the development of PH identified in animal and human studies are summarized.