Total n = 3202a (100)		CP-A n = 1968 (61.5)		CP-B n = 666 (20.8)
	All	DR	All	DR	All	DR
AEs, %b
All grades	85.3	66.0	84.0	68.5	88.6	64.4
Grade 3/4	31.7	23.5	32.4	25.6	31.5	21.9
SAEs	43.3	9.3	36.0	8.8	60.4	14.1
AE rate (event per patient-year)b
Any AE	1.61	1.24	1.44	1.17	2.14	1.55
Diarrhea	0.58	0.51	0.54	0.48	0.71	0.62
Hand-foot skin reaction	0.51	0.50	0.55	0.54	0.42	0.41
Fatigue	0.45	0.29	0.38	0.27	0.62	0.34
Discontinuation due to AEs, %b	31.4		28.9		40.1
Daily dose, median, mgd	688.0		677.0		741.5
Treatment duration, median, weeksd	15.0		17.6		9.9

^aIncludes CP-C, 74 pts; not evaluable, 493 pts

^bTreatment-emergent

^cCalculated based on 365.25 days per year

^dPts with dosing data.