Table 2.

Covariate-adjusted differences in change of hemoglobin A1c

In model 1, which adjusts for baseline age, sex, BMI, and HbA1c, there was no significant difference between groups in change of HbA1c (group II, P=0.066; group III, P=0.678). Additional adjustment of HOMA-β and HOMA-IR did not alter the statistical significance. However, after additional adjustment of daily metformin dose, group II showed a statistically smaller reduction in HbA1c than group I (covariate-adjusted difference in change of HbA1c, 0.35%; P=0.046).

HbA1c, hemoglobin A1c; BMI, body mass index; HOMA-β, homeostasis model assessment of β-cell function; HOMA-IR, homeostasis model assessment of insulin resistance.