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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: Cancer Lett. 2010 Jul 27;298(2):10.1016/j.canlet.2010.07.003. doi: 10.1016/j.canlet.2010.07.003

Fig. 1.

Fig. 1

NAC specifically complexes with copper (Cu), but not zinc (Zn) or iron (Fe), to inhibit cell viability of the A2780 cells. A2780 cells were cultured in RPMI 1640 medium and treated with 0, 1, 10, and 30 µM of CuCl2 (A), ZnCl2 (B), or FeCl3 (C) in the absence or presence of NAC (1 mM) for 72 h and cell viability was examined by the MTS assay. (D) A2780 cells were treated with increasing concentrations of NAC ranging from 0 to 100 µM in the presence of CuCl2 (1 or 10 µM) for 72 h and cell viability was examined by the MTS assay. Data (means ± SD, n = 3) are expressed as percentages of the MTS level detected in untreated control cells.