Table 1.

Structures of compounds 12–40 and their inhibition rates (IC₅₀) to the purified LSD1 recombinant in vitro.

Comp.	R1	R2	IC50(μM)	Comp.	R1	R2	IC50(μM)
12	CH2	o-F	>125	27		p-OCH3	18.4±2.5
13	CH2	p-F	>125	28		m-CH3	43.3±5.9
14	CH2	p-CH3	>125	29		o-CH3	>125
15	CH2	H	>125	30		p-CF3	>125
16	CH2	p-Cl	>125	31		o-CF3	>125
17	0	H	>125	32		o-Br	27.5±3.7
18	0	o-F	>125	33			70.7±1.2
19	0	p-F	>125	34		o-OH	69.2±3.6
20	0	p-CH3	>125	35		p-NO2	>125
21	0	p-Cl	>125	36		m-OH	77.1±3.1
22		o-F	8.0±1.0	37		o, p-diOH	81.3±2.0
23		p-F	21.6±2.3	38		m, p-diC1	88.9±3.2
24		o-Cl	11.5±2.1	39		o, o-diF	51.2±4.3
25		p-Cl	56.5±2.8	40		m,p,m-triOCH3	19.0±2.5
26		p-CH3	2.1±0.7	2-PCPA	-	-	27.8±2.6