Table 4.

The effect of different substituents at the N-atom on LSD1 inhibition.

Comp.	R1	R2	IC50(μM)	Comp.	R1	R2	IC50(μM)
53	CH3	o-F	>125	68		o-F	39.8±1.1
54	CH3	p-CH3	>125	69		p-F	43.9±2.5
55	CH3	p-F	>125	70		p-CH3	35.7±2.0
56	CH3	o-Cl	>125	71		o-F	45.7±1.9
57		p-CH3	>125	72		p-F	55.1±3.3
58		o-F	>125	73	H	o-F	17.3±1.7
59		p-CH3	>125	74	H	p-F	69.3±1.8
60		o-F	>125	75	H	o-Cl	>125
61		p-CH3	83.4±2.1	76	H	p-Cl	>125
62		o-F	100.1±9.3	77	H	p-CH3	28.9±2.0
63		p-F	>125	78	H	p-OCH3	19.5±1.9
64		p-CH3	40.3±2.1	79	H	p-CF3	87.4±2.3
65		o-F	>125	80	H	o, o-diF	>125
66		p-F	>125	81	H	m, p-diCl	>125
67		p-CH3	27.6±1.2	82	H	m,p,m-triOCH3	>125