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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: J Med Chem. 2013 Nov 1;56(21):10.1021/jm401002r. doi: 10.1021/jm401002r

Table 5.

The Effect of the bulk of carbamate moiety on LSD1 inhibition.

graphic file with name nihms-539339-t0046.jpg
Comp. R1 R2 X IC50(μM)
83 graphic file with name nihms-539339-t0047.jpg o-F 0 32.8±2.0
84 graphic file with name nihms-539339-t0048.jpg p-F 0 47.6±4.3
85 graphic file with name nihms-539339-t0049.jpg p-Cl 0 53.2±2.9
86 graphic file with name nihms-539339-t0050.jpg p-Cl 0 >125
87 graphic file with name nihms-539339-t0051.jpg p-CH3 0 22.4±1.0
88 graphic file with name nihms-539339-t0052.jpg p-OCH3 0 35.1±2.1
89 graphic file with name nihms-539339-t0053.jpg m, p-diCl 0 29.5±1.3
90 graphic file with name nihms-539339-t0054.jpg m,p,m-triOCH3 0 43.5±4.1
91 graphic file with name nihms-539339-t0055.jpg p-CH3 0 17.0±1.2
92 graphic file with name nihms-539339-t0056.jpg p-CH3 0 15.0±0.7
93 H o-F CH2 30.2±1.9
94 H p-F CH2 47.1±2.0
95 H p-CH3 CH2 25.3±2.2