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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: Chem Rev. 2009 Oct;109(10):10.1021/cr900006y. doi: 10.1021/cr900006y

Figure 3.

Figure 3

Zinc proteome of yeast mitochondria. A subset of the Zn(II) metalloproteins of yeast mitochondria are shown. A myriad of IM-associated metalloproteinases use Zn(II) as a catalytic cofactor. These include the mAAA, iAAA, Omal proteases of the IM, and the IMS protease Atp23. The mitochondrial processing protease (MPP) that functions in cleavage of the N-terminal mitochondrial targeting sequence consists of two subunits, Masl and Mas2, that are metal-dependent, most likely with Zn(II).44 Another component of the protein import machinery is the Zn-requiring Ziml7, which functions with the Hsp70 protein Sscl to facilitate protein import.48 The DnaJ protein Mdj 1 contains a Cys-rich motif consistent with Mdj 1 being a Zn-dependent enzyme. One subunit, Mrpl32, of the mitoribosome is a candidate Zn(II) stabilized protein. Cytochrome oxidase contains an essential Zn-containing subunit, Cox4 in yeast.170