Table 2.

Adipokines decreased in obesity and/or diabetes (adapted and updated from [85]).

Adipokine	Distribution	Function	Decreased in obesity
Adiponectin	Only secreted by adipose tissue. Lower production in men	Insulin sensitizing effect. Improves insulin resistance and glucose metabolism	Decreased in mouse models of obesity. Decreased in human obesity and correlated negatively with BMI. Increased after weight loss
IL-10	Secreted by monocytes, macrophages, dendritic cells, and B and T cells	Improves insulin sensitivity and glucose transport	Attenuated in T2D patients and increased with weight loss
Omentin	Expressed in heart, lungs, ovary, and placenta and predominantly produced by WAT	Improve glucose uptake in human adipocytes and has an anti-inflammatory effect	Decreased circulating levels in obese subjects. In impaired glucose tolerant (IGT) and subjects with T2D, circulating levels are lower those when compared with matched controls