Table 2B.
Histopathologic features of melanoma by p53 Arg72Pro genotype
| Women (N=87) | Men (N=126) | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Patient and Tumor Characteristics | RR N (%) |
RP N (%) |
PP N (%) |
P value | RR N (%) |
RP N (%) |
PP N (%) |
P value |
| All Melanoma Patients | 52 (59.8) | 29 (33.3) | 6 (6.9) | -- | 71 (56.3) | 46 (36.5) | 9 (7.1) | -- |
| History of multiple melanoma | 7 (13.5) | 3 (10.3) | 0 (0.0) | 1 | 6(9.0) | 9 (20.0) | 1 (11.1) | 0.27 |
| Family history of melanoma | 8 (17.0) | 1 (3.4) | 1 (20.0) | 0.18 | 6 (8.5) | 5 (10.9) | 1 (11.1) | 1 |
| Stage of disease | ||||||||
| I | 43 (82.7) | 22 (75.9) | 4 (66.7) | 0.53 | 54 (76.1) | 31 (67.4) | 5 (55.6) | 0.47 |
| II | 7 (13.5) | 5 (17.2) | 1 (16.7) | 11 (15.5) | 10 (21.7) | 2 (22.2) | ||
| III | 2 (3.8) | 2 (6.9) | 1 (16.7) | 6 (8.5) | 5 (10.9) | 2 (22.2) | ||
| Histologic Type | ||||||||
| SS | 28 (53.8) | 14 (48.3) | 2 (33.3) | 0.81 | 32 (45.1) | 21 (45.7) | 4 (44.4) | 0.89 |
| Nodular | 7 (13.5) | 6 (20.7) | 2 (33.3) | 16 (22.5) | 14 (30.4) | 3 (33.3) | ||
| Other | 9 (17.3) | 6 (20.7) | 1 (16.7) | 9 (12.7) | 6 (13.0) | 1 (11.1) | ||
| Unclassified | 8 (15.4) | 3 (10.3) | 1 (16.7) | 14 (19.7) | 5 (10.9) | 1 (11.1) | ||
| Tumor thickness, mm (median, IQR) | 0.70 (0.91) | 0.77 (1.05) | 0.88 (8.04) | 0.83* | 0.76 (1.15) | 0.90 (1.48) | 1.70 (2.33) | 0.07* |
| Anatomic site | ||||||||
| Axial | 20 (38.5) | 13 (44.8) | 2 (33.3) | 0.78 | 52 (73.2) | 33 (71.7) | 6 (66.7) | 0.86 |
| Extremity | 32 (61.5) | 16 (55.2) | 4 (66.7) | 19 (26.8) | 13 (28.3) | 3 (33.3) | ||
| Ulceration | 6 (11.5) | 4 (13.8) | 2 (33.3) | 0.26 | 9 (12.7) | 9 (19.6) | 3 (33.3) | 0.2 |
| Recurrence | 2 (3.8) | 2 (6.9) | 1 (16.7) | 0.31 | 4 (5.6) | 4 (8.7) | 1 (11.1) | 0.63 |
P value calculated by Fisher’s Exact Test unless otherwise specified.
*
Kruskal-Wallis test
Unknown values are not included in the table. Stage of disease was at time of recruitment. SS=Superficial spreading. “Other” is comprised of desmoplastic, lentigo maligna, and acral lentiginous, as well as those melanomas that did not fit into one histologic category.