From left to right, voxel-based detected patterns of gray matter volumes reductions on MRI (atrophy), reduced brain glucose metabolism on FDG PET and increased amyloid-beta load on PiB-PET in NL FHm compared to FHp and FH- (114, 120, 125, 126). Statistical maps were obtained using voxel-based morphometry for MRI, and PET voxel-based analysis for FDG and PiB PET as implemented in Statistical Parametric Mapping (SPM).