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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Clin Transl Imaging. 2013 Aug;1(4):10.1007/s40336-013-0026-y. doi: 10.1007/s40336-013-0026-y

Figure 4. Biomarker abnormalities in cognitively normal individuals with a maternal history of late-onset AD.

Figure 4

From left to right, voxel-based detected patterns of gray matter volumes reductions on MRI (atrophy), reduced brain glucose metabolism on FDG PET and increased amyloid-beta load on PiB-PET in NL FHm compared to FHp and FH- (114, 120, 125, 126). Statistical maps were obtained using voxel-based morphometry for MRI, and PET voxel-based analysis for FDG and PiB PET as implemented in Statistical Parametric Mapping (SPM).