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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: Mol Cancer Res. 2009 Nov 10;7(11):10.1158/1541-7786.MCR-09-0255. doi: 10.1158/1541-7786.MCR-09-0255

Figure 5.

Figure 5

Cav-1 promotes cancer cell migration/motility. A and B. Wound healing assay. A. Representative images showing increased cell migration to the wounded area (clear area, defined by dashed lines) in Adcav-1–infected LNCaP cells and decreased cell migration to the wounded area in cav-1 siRNA–transfected DU145 and PC-3 cells. PI3-K-Akt inhibitor LY effectively blocked cancer cell migration. B. Quantitative analysis of triplicate wound healing assay experiments. C and D, Transwell chamber assays. C. Representative images showing increased transwell cell migration in Adcav-1–infected LNCaP cells and decreased migration in cav-1 siRNA–transfected DU145 and PC-3 cells. LY significantly reduced transwell cell migration. D. Quantitative analysis of triplicate Transwell migration assay experiments. In b and d, error bars indicate SD, * is used for the comparison to control AdRSV or NC siRNA, and ♦ is used for the comparison of Adcav-1 + LY with Adcav-1. * or ♦ stands for statistically significant (P < 0.05), and ** or ♦♦ stands for statistically very significant (P < 0.0001).