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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: J Infect Dis. 2009 Jul 15;200(2):10.1086/599795. doi: 10.1086/599795

Figure 2.

Figure 2

Suppression of tumor necrosis factor (TNF)–α–driven endothelium hyperpermeability and mediation of the early barrier-enhancing effects of dengue virus type 2 (DENV2) infection by type I interferon (IFN). Recombinant (r) TNF-α–mediated increases in human umbilical vein endothelial cell (HUVEC) monolayer permeability to 70-kDa dextran were measured 72 h after the addition of rIFN-β or DENV2 infection (multiplicity of infection, 0.5) with or without a type I IFN signaling antagonist (rB18R). A, Effect of rIFN-β on rTNF-α–mediated hyperpermeability. B, Effect of type I IFN antagonism on the DENV2 suppression of rTNF-α–mediated macromolecule permeability. BSA, bovine serum albumin. Data are means ± standard errors from 2 experiments.