Table 2. Representative enriched GO terms for the human sperm proteome.
| Class | Accession | Description | Count | Enrichment | FDR |
|---|---|---|---|---|---|
| CC | GO:0043226 | Organelle | 4037 | 1.2 | 1.2E-155 |
| CC | GO:0005739 | Mitochondrion | 715 | 1.8 | 4.9E-91 |
| CC | GO:0043234 | Protein complex | 1357 | 1.5 | 1.7E-74 |
| CC | GO:0042470 | Melanosome | 69 | 2.2 | 1.3E-11 |
| CC | GO:0030117 | Membrane coat | 50 | 2.2 | 2.3E-08 |
| CC | GO:0070469 | Respiratory chain | 56 | 2.1 | 7.8E-08 |
| BP | GO:0055114 | Oxidation reduction | 367 | 1.5 | 7.4E-22 |
| BP | GO:0006119 | Oxidative phosphorylation | 71 | 1.9 | 2.0E-08 |
| BP | GO:0006732 | Coenzyme metabolic process | 98 | 1.7 | 1.6E-07 |
| BP | GO:0006007 | Glucose catabolic process | 47 | 2.2 | 2.0E-07 |
| BP | GO:0006096 | Glycolysis | 37 | 2.1 | 1.2E-04 |
| BP | GO:0006099 | Tricarboxylic acid cycle | 22 | 2.5 | 2.4E-04 |
| MF | GO:0003824 | Catalytic activity | 2624 | 1.3 | 7.8E-122 |
| MF | GO:0000166 | Nucleotide binding | 1263 | 1.5 | 2.4E-82 |
| MF | GO:0016491 | Oxidoreductase activity | 392 | 1.5 | 6.4E-23 |
| MF | GO:0048037 | Cofactor binding | 164 | 1.8 | 2.2E-16 |
| MF | GO:0050662 | Coenzyme binding | 127 | 1.9 | 1.5E-15 |
| MF | GO:0051287 | NAD or NADH binding | 36 | 2.0 | 4.7E-04 |
Abbreviations: BP, biological process; CC, cellular component; GO, Gene Ontology; MF, molecular function.
The enrichment analysis was performed with Fisher's exact test using DAVID; the human genome was set as the background. The FDR represents false discovery rate, which was set to FDR<0.05 to control for significant enrichment.