Table 5.
This is a summary of studies comparing the oral antibiotic bowel preparation plus systemic antibiotics versus systemic antibiotics alone in elective colon surgery. Only studies with a total study population of 100 or more patients are included. The oral antibiotics used are indicated.
| Author, (year) | Combined antibiotics received | Oral and IV antibiotics | IV Antibiotics only | Comments | ||
|---|---|---|---|---|---|---|
| SWI | No. of patients | SWI | No. of patients | |||
| Kaiser et al. (1983) [77] | Neo-erythro | 2 (3%) | 63 | 7 (12.5%) | 56 | P < 0.06; P < 0.05 for operations > 4 hrs in duration |
| Lau et al. (1988) [78] | Neo-erythro | 3 (5%) | 65 | 5 (7.5%) | 67 | No statistical difference |
| Coppa and Eng (1988) [79] | Neo-erythro | 9 (5%) | 169 | 15 (11%) | 141 | P < 0.11 |
| Reynolds et al. (1989) [80] | Neo-metro | 9 (8%) | 107 | 26 (12%) | 223 | No statistical difference |
| Khubchandani et al. (1989) [81] | Neo-erythro | 5 (9%) | 55 | 14 (30%) | 47 | P < 0.03 (P < 0.05 with Yates' correction) |
| Taylor and Lindsay (1994) [82] | Ciprofloxacin | 17 (11%) | 159 | 30 (18%) | 168 | P < 0.11; no published evidence to support ciprofloxacin. |
| McArdle et al. (1995) [83] | Ciprofloxacin | 8 (10%) | 82 | 20 (23%) | 87 | P < 0.05; no published evidence to support ciprofloxacin. |
| Lewis (2002) [101] | Neo-metro | 5 (5%) | 104 | 17 (16.5%) | 103 | P < 0.01 |