Figure 1.

Mikania laevigata extract (MLE) decreases alveolar bone resorption. Histology at the furcation of first molars sampled from the rats euthanized after 30 days of experiments is shown [hematoxylin and eosin(HE) staining]; (A) non-ligated animals treated with vehicle, (B) non-ligated animals treated with (MLE) (10 mg/kg/day for 30 consecutive days), (C) ligature-induced periodontitis treated with vehicle for 30 days, (D) ligature-induced periodontitis treated with subcutaneous MLE (10 mg/kg/ day for 30 consecutive days). (E) Results are expressed as mean area (mm²) ± standard deviation of 10 animals in each group. Different symbols indicate intergroup statistical significance (ANOVA followed by Bonferroni’s test). Magnification at 40× objective (scale bar=100 μm)