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. 2013 Oct 23;7(1):119–128. doi: 10.1242/dmm.012500

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Genome-wide association mapping for the hamartoma disease locus. (A) Manhattan plot for case/control GWAS presenting a unique genome-wide significant signal on chromosome 25; the 29 autosomes are alternately labeled in gray or black. inset shows a typical hamartoma case. (B) Cases genotypes for 1256 chromosome 25 SNP; homozygous genotypes are shown in yellow or white, heterozygous genotypes in red; the centromeric 1.15-Mb homozygosity region, identical by state among all cases, is highlighted in red.