Table 3.
Parameter | Consequences |
---|---|
↑Total body water, extracellular fluid | Altered drug distribution |
↑Fat stores | ↓Elimination of lipid soluble drugs |
↑Cardiac output | ↑Hepatic blood flow leading to ↑elimination |
↑Renal blood flow and glomerular flow rate | ↑Renal clearance of unchanged drug |
Altered CYP3A4 activity and UGT activity | Altered systemic absorption & hepatic elimination |
↓Maternal albumin | Altered free fraction; increased availability of drug for hepatic extraction |
From Pennell, 2003.