Table 1.
Recipient, donor, and transplant characteristics
| Baseline characteristics | Total (n = 477) | Pre (n = 124) | Post (n = 353) | P value |
|---|---|---|---|---|
|
Recipient characteristics | ||||
| Mean recipient age (years) |
477 |
48.5 ± 13.3a |
51.3 ± 13.1 |
0.04 |
| Recipient sex |
0.14 |
|||
| Male |
296 |
70 (56.5%) |
226 (64.0%) |
|
| Female |
181 |
54 (43.6%) |
127 (36.0%) |
|
| Race |
|
|
|
0.19 |
| Caucasian |
289 |
69 (55.7%) |
220 (62.3%) |
|
| Non-Caucasian |
188 |
55 (44.4%) |
133 (37.7%) |
|
| Mean height (cm) |
477 |
167.9 ± 11.9 |
168.1 ± 9.9 |
0.83 |
| Mean weight (kg) |
477 |
77.7 ± 18.1 |
75.1 ± 16.3 |
0.13 |
| Body mass index (kg/m2) |
477 |
27.6 ± 5.8 |
26.5 ± 5.2 |
0.07 |
| Cause of ESRD |
0.58 |
|||
| Diabetes |
83 |
17 (13.7%) |
66 (18.7%) |
|
| Glomerulonephritis |
171 |
51 (41.1%) |
120 (34.0%) |
|
| Polycystic kidney disease |
55 |
15 (12.1%) |
40 (11.3%) |
|
| Hypertension |
48 |
12 (9.7%) |
36 (10.2%) |
|
| Other |
120 |
29 (23.4%) |
91 (25.8%) |
|
| Transplant number |
0.57 |
|||
| First graft |
396 |
105 (84.7%) |
291 (82.4%) |
|
| Re-graft |
81 |
19 (15.3%) |
62 (17.6%) |
|
| Median PRA (%)b |
477 |
15 (0,49) |
10 (0,46) |
0.23 |
| Median length of stay (days)b |
477 |
9 (7,12) |
11 (8,16) |
0.01 |
|
Donor characteristics | ||||
| Mean donor age (years) |
477 |
45.8 ± 13.9 |
48.5 ± 14.2 |
0.05 |
| Donor sex |
1.00 |
|||
| Male |
250 |
65 (52.4%) |
185 (52.4%) |
|
| Female |
227 |
59 (47.8%) |
168 (47.6%) |
|
| Median donor CrCl (mL/min)b, c |
445 (117/328)d |
110.6 (92.9, 137.6) |
110.5 (91.5, 140.9) |
0.88 |
| Mean CIT (min)e |
244 (38/206)d |
954.7 ± 314.7 |
810.7 ± 375.2 |
0.03 |
| Donor type (%) |
0.002 |
|||
| Deceased |
312 |
67 (54.0%) |
245 (69.4%) |
|
| Living |
165 |
57 (46.0%) |
108 (30.6%) |
|
| DCD kidneys |
|
|||
| No |
443 |
124 (100%) |
319 (90.4%) |
<0.001 |
| Yes |
34 |
0 (0%) |
34 (9.6%) |
|
|
Transplant characteristics | ||||
| Transplant era (%) |
|
|
|
<0.001 |
| 2002 to 2004 |
86 |
31 (25.0%) |
55 (15.6%) |
|
| 2005 to 2007 |
186 |
61 (49.2%) |
125 (35.4%) |
|
| 2008 to 2009 |
205 |
32 (25.8%) |
173 (49.0%) |
|
| Delayed graft function |
|
|
|
|
| No |
332 |
99 (79.8%) |
233 (66.0%) |
0.004 |
| Yes |
145 |
25 (20.2%) |
120 (34.0%) |
|
| Maintenance CNI |
<0.001 | |||
| Tacrolimus |
360 |
78 (62.9%) |
282 (79.9%) |
|
| Cyclosporine |
106 |
45 (36.3%) |
61 (17.3%) |
|
| CNI-free | 11 | 1 (0.8%) | 10 (2.8%) | |
CIT, cold ischemia time; CNI, calcineurin inhibitor; CrCl, creatinine clearance; DCD, donation after cardiac death; ESRD, end stage renal disease; PRA, panel reactive antibodies.
aPlus-minus values are means ± standard deviation.
bMedian (interquartile range).
cCreatinine clearance estimated using the Cockcroft-Gault formula.
dTotal number assessed (Pre group/Post group).
eDeceased donor kidney transplants only.