Table 4.
Cox model for biopsy-proven acute rejection, graft loss and death (n = 477) over 5-year follow-up
| Number of events a | Pre (n = 124) b | Post (n = 353) b | Hazard Ratio (95% CI) c | P value | |
|---|---|---|---|---|---|
| BPAR |
68 (19/49) |
17.6% |
15.5% |
0.90 (0.50, 1.64) |
0.73 |
| Graft loss |
29 (8/21) |
8.6% |
10.1% |
1.04 (0.41, 2.61) |
0.94 |
| Death |
26 (10/16) |
9.8% |
6.3% |
0.54 (0.21, 1.39) |
0.20 |
| Composite | 103 (29/74) | 27.0% | 25.7% | 0.94 (0.58, 1.53) | 0.81 |
aTotal number of events (Pre group/Post group).
bCumulative probability of the outcome at 5-years using the Kaplan-Meier product limit method.
cPredictors in the Cox model include: timing of induction, indication (high risk recipient and donor, high immunologic risk recipient, high risk donor and low immunologic risk recipient), occurrence of DGF, weight-adjusted total rATG dose, recipient age, recipient sex, recipient race (Caucasian or non-Caucasian), cause of ESRD (diabetes or non-diabetes), time on dialysis, peak PRA, re-graft status, recipient BMI, donor age, donor sex, donor type (living or deceased), and transplant era (2002 to 2004, 2005 to 2007 and 2008 to 2009).
BMI, body mass index; BPAR, biopsy-proven acute rejection; CI, confidence interval; DGF, delayed graft function; ESRD, end stage renal disease; PRA, panel reactive antibodies; rATG, rabbit antithymocyte globulin.