Table 3.
Top 30 strongest SNPs interacting with occupational exposure to affect FEV 1
| SNP | Chr | Position | Band | Gene | All1 | All2 | MAF | β SNP | P SNP | β interaction | P interaction |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs9931086 |
16 |
84046105 |
q23.3 |
SLC38A8 |
A |
C |
0.19 |
27.70 |
2.53E-02 |
-214 |
1.16E-07* |
| rs11252277 |
10 |
4065704 |
p15.1 |
|
G |
A |
0.09 |
2.90 |
1.05E-01 |
-263 |
6.32E-07 |
| rs3889785 |
4 |
165097529 |
q32.3 |
MARCH1 |
A |
C |
0.13 |
-2.02 |
1.69E-01 |
237 |
1.05E-06 |
| rs7098287 |
10 |
4050329 |
p15.1 |
|
G |
C |
0.09 |
3.60 |
4.88E-02 |
-247 |
2.47E-06 |
| rs32977 |
5 |
14119057 |
p15.2 |
|
A |
G |
0.06 |
5.50 |
7.38E-03 |
-310 |
3.98E-06 |
| rs17508671 |
2 |
185491847 |
q32.1 |
ZNF804A |
A |
G |
0.16 |
-0.27 |
8.32E-01 |
-173 |
4.45E-06 |
| rs2544785 |
19 |
49085710 |
q13.33 |
SULT2B1 |
C |
T |
0.16 |
0.03 |
0.983642 |
172 |
4.57E-06 |
| rs4234966 |
4 |
165078580 |
q32.3 |
MARCH1 |
C |
G |
0.12 |
-1.92 |
1.88E-01 |
217 |
6.35E-06 |
| rs32978 |
5 |
14119645 |
p15.2 |
|
C |
T |
0.05 |
5.05 |
1.75E-02 |
-302 |
6.63E-06 |
| rs32979 |
5 |
14119775 |
p15.2 |
|
T |
C |
0.05 |
5.05 |
1.75E-02 |
-302 |
6.63E-06 |
| rs17645582 |
6 |
82797317 |
q14.1 |
|
C |
T |
0.07 |
-1.07 |
5.75E-01 |
208 |
6.89E-06 |
| rs4932559 |
15 |
92133594 |
q26.1 |
|
A |
G |
0.36 |
-1.62 |
0.081898 |
132 |
7.10E-06 |
| rs745926 |
2 |
120482057 |
q14.2 |
|
T |
G |
0.41 |
-1.13 |
2.24E-01 |
136 |
9.90E-06 |
| rs1561577 |
15 |
89146968 |
q26.1 |
|
A |
G |
0.07 |
-3.17 |
0.104592 |
224 |
1.16E-05 |
| rs6445707 |
3 |
54881562 |
p14.3 |
CACNA2D3 |
G |
A |
0.18 |
0.40 |
7.47E-01 |
166 |
1.17E-05 |
| rs2544784 |
19 |
49085733 |
q13.33 |
SULT2B1 |
A |
T |
0.16 |
0.00 |
0.997879 |
161 |
1.25E-05 |
| rs17110400 |
14 |
26276467 |
q12 |
|
C |
T |
0.09 |
-0.31 |
0.855973 |
265 |
1.53E-05 |
| rs10231843 |
7 |
103884705 |
q22.2 |
|
C |
G |
0.27 |
-1.10 |
3.09E-01 |
160 |
1.64E-05 |
| rs17430621 |
2 |
185492469 |
q32.1 |
ZNF804A |
A |
T |
0.16 |
0.02 |
9.85E-01 |
-165 |
1.89E-05 |
| rs163814 |
5 |
14122497 |
p15.2 |
|
C |
T |
0.05 |
5.43 |
1.16E-02 |
-285 |
1.94E-05 |
| rs477920 |
1 |
74767844 |
p31.1 |
FPGT TNNI3K |
A |
G |
0.17 |
0.23 |
8.55E-01 |
-183 |
2.04E-05 |
| rs6972824 |
7 |
157473222 |
q36.3 |
PTPRN2 |
C |
A |
0.11 |
2.38 |
8.22E-02 |
-196 |
2.30E-05 |
| rs6124623 |
20 |
42746332 |
q13.12 |
JPH2 |
C |
G |
0.14 |
1.34 |
3.00E-01 |
-172 |
2.34E-05 |
| rs2832081 |
21 |
30152992 |
q21.3 |
|
C |
A |
0.31 |
-2.33 |
0.01353 |
137 |
2.36E-05 |
| rs7356986 |
6 |
12301462 |
p24.1 |
|
G |
A |
0.11 |
-1.68 |
3.20E-01 |
202 |
2.36E-05 |
| rs41328144 |
1 |
166319711 |
q24.1 |
|
C |
T |
0.13 |
-0.68 |
6.35E-01 |
155 |
2.54E-05 |
| rs2803543 |
10 |
88301331 |
q23.2 |
|
G |
A |
0.10 |
-2.35 |
1.49E-01 |
224 |
2.90E-05 |
| rs163813 |
5 |
14122154 |
p15.2 |
|
G |
A |
0.05 |
5.00 |
1.88E-02 |
-281 |
2.96E-05 |
| rs17508706 |
2 |
185524591 |
q32.1 |
ZNF804A |
G |
A |
0.16 |
-0.14 |
9.12E-01 |
-162 |
3.04E-05 |
| rs4130671 | 7 | 119277137 | q31.31 | A | C | 0.49 | -1.37 | 1.27E-01 | 122 | 3.71E-05 |
SNP-estimates are based on an additive model. Beta-estimates represent the increase or decrease FEV1 in mL.
*Significant after Bonferroni correction for testing 300,709 SNPs (α = 1.66E-07).
Chr: Chromosome; All1: allele1; All2: allele2.