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The effects of combinations of NVP-AEW541 with MK2206, BEZ235, or RAD001 inhibitors on downstream signaling activity (A) and apoptosis-related proteins (B) in HCC cells. Effects on phosphorylation of Akt, P70S6K, and 4EBP-1 were examined by Western blotting. HCC cells (Hep3B and Huh7) were treated with or without NVP-AEW541 and MK2206, BEZ235, or RAD001 at the indicated concentrations and times. Whole-cell lysates were subjected to Western blotting.
