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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: J Nucl Med. 2013 Jul 5;54(8):10.2967/jnumed.112.118232. doi: 10.2967/jnumed.112.118232

TABLE 1.

Outcome Parameters for Whole Brain Gray Matter of the 1T2K and 2T4K Models * for 11C-Tariquidar and 11C-Elacridar

1T2K 2T4K
11C-tariquidar 11C-elacridar 11C-tariquidar 11C-elacridar
K1
(mL·mL−1·min−1)		 0.003±0.001
(0.002-0.004)		 0.003±0.001
(0.002-0.003)		 0.004±0.001
(0.003-0.004)		 0.005±0.001
(0.004-0.005)
k2 (min−1) 0.013±0.003
(0.010-0.016)		 0.012±0.003
(0.009-0.014)		 0.076±0.023
(0.055-0.097)		 0.124±0.031
(0.094-0.155)
k3 (min−1) 0.100±0.031
(0.073-0.127)		 0.108±0.032
(0.076-0.140)
k4 (min−1) 0.016±0.007
(0.010-0.022)		 0.014±0.006
(0.007-0.020)
VT (mL·mL−1) 0.23±0.04
(0.20-0.27)		 0.24±0.09
(0.15-0.33)		 0.35±0.07
(0.29-0.42)		 0.36±0.07
(0.29-0.43)
V b 0.050±0.008
(0.043-0.057)		 0.046±0.003
(0.042-0.049)		 0.046±0.006
(0.042-0.051)		 0.042±0.003
(0.038-0.045)
AIC −34.1±8.5 −33.8±7.7 −42.2±6.3 −49.7±1.9
*

Data from 0-60 min was used and plasma input function was not corrected for radiolabeled metabolites.

Outcome parameters are given as mean ± SD (11C-tariquidar: n = 5, 11C-elacridar: n = 4, subject 10 excluded). In parentheses the 95% confidence intervals of the mean parameter estimates are given. K1, k2, k3, k4 : rate constants for exchange of radioactivity between plasma and brain compartments; VT : distribution volume; Vb : blood volume fraction in brain; AIC: Akaike information criterion