TABLE 1.
1T2K | 2T4K | |||
---|---|---|---|---|
11C-tariquidar | 11C-elacridar | 11C-tariquidar | 11C-elacridar | |
K1 (mL·mL−1·min−1) |
0.003±0.001 (0.002-0.004) |
0.003±0.001 (0.002-0.003) |
0.004±0.001 (0.003-0.004) |
0.005±0.001 (0.004-0.005) |
k2 (min−1) | 0.013±0.003 (0.010-0.016) |
0.012±0.003 (0.009-0.014) |
0.076±0.023 (0.055-0.097) |
0.124±0.031 (0.094-0.155) |
k3 (min−1) | 0.100±0.031 (0.073-0.127) |
0.108±0.032 (0.076-0.140) |
||
k4 (min−1) | 0.016±0.007 (0.010-0.022) |
0.014±0.006 (0.007-0.020) |
||
VT (mL·mL−1) | 0.23±0.04 (0.20-0.27) |
0.24±0.09 (0.15-0.33) |
0.35±0.07 (0.29-0.42) |
0.36±0.07 (0.29-0.43) |
V b | 0.050±0.008 (0.043-0.057) |
0.046±0.003 (0.042-0.049) |
0.046±0.006 (0.042-0.051) |
0.042±0.003 (0.038-0.045) |
AIC | −34.1±8.5 | −33.8±7.7 | −42.2±6.3 | −49.7±1.9 |
Data from 0-60 min was used and plasma input function was not corrected for radiolabeled metabolites.
Outcome parameters are given as mean ± SD (11C-tariquidar: n = 5, 11C-elacridar: n = 4, subject 10 excluded). In parentheses the 95% confidence intervals of the mean parameter estimates are given. K1, k2, k3, k4 : rate constants for exchange of radioactivity between plasma and brain compartments; VT : distribution volume; Vb : blood volume fraction in brain; AIC: Akaike information criterion