Figure 11. Comparison of Base Case (k₇ = 0.1) with the Case k₇ = 100.

Red curves are the steady-state curves for the base case (k₇ = 0.1). Green curves are the same curves when k₇ = 100. Intersections of red and green curves with the black define the steady-states for the two cases. Solid blue curve is the state trajectory for the base case. Dashed blue curve is the state trajectory for the case when k₇ = 100. As the effect of Ang II is increased by increasing k₇, the system loses bistability. Trajectories converge to the single steady-state S₁ at low levels of pAKT and NO.