Table 1. SCLC cell lines: mutational status and IC50 values.

BMN 673 and cisplatin IC50 values calculated from proliferation assays. Mutational status of SCLC cell lines tested for TP53, RB1 and myc amplification (mt = mutant, wt = wild type, unk = unknown) are shown.

Cell Line	TP53	RB1	myc amp.	BMN 673 IC50 (nM)	Cisplatin IC50 (nM)
H209*	mt	mt	none	1.7	45.5
H1048	mt	mt	none	2.2	1087
H524*	mt	mt	myc	3.1	976
H1930*	mt	wt	none	4.1	153
H69*	mt	mt	n-myc	5.2	2723
H2081	wt	mt	none	6.3	2669
H2107*	mt	mt	l-myc	7.3	811
H1092*	mt	wt	l-myc	8.9	1611
DMS-79*	mt	mt	none	9.3	1189
H446*	mt	mt	myc	13	2074
COR-L279	mt	mt	unk	15	620

^*Protein profile included in proteomic analysis