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. 2014 Jan 6;9(1):e84374. doi: 10.1371/journal.pone.0084374

Figure 1. Interplaying signaling pathways responsible for the modulation of axonal survival and death.

Figure 1

NGF, nerve growth factor; proNGF, NGF precursor; TrkA, tyrosine kinase receptor A, p75NTR, neurotrophin receptor p75; Sema3A, semaphorin 3A; JNK, c-Jun N-terminal kinase; RhoA, Ras homolog family member A; ROCK, Rho kinase; MAPK/ERK, mitogen activated protein kinase; AKT, protein kinase B; nNOS, neuronal nitric oxide synthase; NO, nitric oxide; Casp-7, cleaved caspase 7; PARP, poly(ADP-ribose) polymerase.